Insulin Resistance

Insulin Resistance is a condition that involves a decrease in the sensitivity of the body’s Cells to the actions of Insulin (i.e. a decrease in Insulin Sensitivity).  Insulin Resistance is characterized by decreased sensitivity of Insulin Receptors for Insulin.  This lack of sensitivity to the effects of Insulin results in ever-increasing production of Insulin, to the extent that dangerously high levels of Insulin can occur. 25% of the population of the United States has Insulin Resistance (presumably this statistic would apply also to most other Western nations). Insulin facilitates the transport of Vitamin C into Cells and the Insulin Resistance that afflicts Diabetes Mellitus patients may therefore impair the transport of Vitamin C into Cells.
– 6.7% of persons aged 20 – 29 have Insulin Resistance.
– 43.5% of persons aged 60 – 70 have Insulin Resistance

 Substances may Cause Insulin Resistance
Excessive consumption of Fructose may cause Insulin Resistance
Excessive consumption ofSucrose may cause Insulin Resistance
Excessive consumption ofCarbohydrates may cause Insulin Resistance
Excessive  consumptionCaffeine may cause Insulin Resistance
Excessive consumption of Soft Drinks may cause Insulin Resistance
Excessive consumption of Alcohol may cause Insulin Resistance
Excessive endogenous production or release o fInsulinmay cause Insulin Resistance (via a Negative feedback)
Excessive production of Cortisol may cause Insulin Resistance in the Muscles
ExogenousEstrogensmay increase the risk of Insulin Resistance in postmenopasual women using Estrogens as part of Hormone Replacement Therapy (HRT)
Excessive consumption of Saturated Fatty Acids and Trans-fatty Acid may cause Insulin Resistance
C-Reactive Protein is a biomarker of Insulin Resistance
Elevated Uric Acid levels may cause Insulin Resistance
Obesity may increase the risk of Insulin Resistance
Excessive Stress may cause Insulin Resistance
A high Glycemic Index diet may increase the risk of Insulin Resistance

Insulin Resistance may be Associated with these Ailments
– Insulin Resistance
may increase the risk of Heart Attack
– Insulin Resistance
may increase the risk of Ischemic Heart Disease (due to the elevated Insulin levels that are associated with Ischemic Heart Disease)
Insulin Resistance may cause Hypertension
– Insulin Resistance
may cause Stroke
– Insulin Resistance
may contribute to the development of Alzheimer’s Disease
– Insulin Resistance
is a symptom of and is the primary feature of Diabetes Mellitus Type 2
– insulin Resistance
may increase the risk of Atherosclerosis
– Insulin Resistance
may increase the risk of Breast Cancer
– Insulin Resistance
may increase the risk ofProstate Cancer
– Insulin Resistance
may causePolycystic Ovary Syndrome (PCOS) , there is some evidence that Insulin Resistance is the principal underlying cause of (PCOS)
– Insulin Resistance
may cause the Nonalcoholic Steatohepatitis (NASH) form of Fatty Liver
– Insulin Resistance
may result in elevated serum Cholesterol, Triglycerides levels and lower the HDL Cholesterol
Insulin Resistance may be the underlying cause of Fatigue

Substances may Decrease Insulin Resistance
some Amino acid may reduce Insulin Resistance (Arginine, Leucine, Taurine and NAC)
– DHEA
– Testosterone
– Melatonin

Lipids
      – Conjugated Linoleic Acid (CLA)
– Gamma Linolenic Acid
(GLA)
– Alpha-Linolenic Acid
(LNA)
     – Omega-3Fatty Acid
– Docosahexaenioc Acid
(DHA)
– Eicosapentaenoic Acid
(EPA)

Minerals
– Calcium
– Magnesium
– Potassium
– Selenium
– Chromium
– Zinc
– Coenzym Q10
may reduce Insulin Resistance

Vitamins
– Vitamin C
– Folic Acid
– Vitamin A
– Biotin
– Vitamin D
– Vitamin E
– Vitamin K
– Lipoic Acid

Herbs
– Ginger
– Cinnamon
– Bitter Melon
– Green Tea
– Chia seeds
– Grape Seeds
– Fengreek Seeds

Dietary oils
– Fish oil
– Cod liver Oil

Exercise
– Regular Exercise
may reduce Insulin Resistance
– Aerobic
– Isotonic

 

 

 

Dr. Said Sokhandan
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